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The main active agents in zestoretic, lisinopril and hydrochlorothiazide, work in combination to lower blood pressure.

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ACE-inhibitors and angiotensin II receptor blockers should not be used concomitantly in patients with diabetic nephropathy.

A very serious allergic reaction to this drug is rareHoweverget medical help right away if you notice any symptoms of a serious allergic reactionincludingrashitching/swellingespecially of the face/tongue/throatsevere dizzinesstrouble breathing.

There is evidence that the concomitant use of ACE-inhibitorsangiotensin II receptor blockers or aliskiren increases the risk of hypotensionhyperkalaemia and decreased renal functionincluding canadian drug plans. acute renal failureDual blockade of RAAS through the combined use of ACE-inhibitorsangiotensin II receptor blockers or aliskiren is therefore not recommendedsee sections 4.5 and 5.1

Tell your doctor if your condition does not get better or if it gets worsefor exampleyour blood pressure readings remain high or increase

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