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Because tetracyclines have been shown to depress plasma prothrombin activitypatients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage.
The broad-spectrum effectiveness of Terramycin against both gram-positive and gram-negative organisms is enhanced by the particular effectiveness of polymyxin B against infections associated with gram-negative organismsespecially those due to Pseudomonas aeruginosawhere polymyxin B is the antibiotic of choiceIn additionthere is evidence to indicate that polymyxin B sulfate possesses some antifungal activityThe combined antibacterial effect of Terramycin plus polymyxin is at least additive andin many instancesan synthroid uk. actual synergistic action is obtained.
Because many strains of the following groups of microorganisms have been shown to be resistant to tetracyclinesculture and susceptibility testing are recommended.
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